Pneumonia has many possible causes, but the most common ones are bacteria and viruses normally encountered in the environment. Usually your body keeps these microbes from invading your lungs. Sometimes, though, a robust germ can breach your defenses, regardless of your general health.
The germs that cause pneumonia in otherwise healthy people are not usually the same ones that cause pneumonia in hospitals and other health care settings. Similarly, the germs that can infect your lungs if you inhale foreign substances (inhalation or aspiration pneumonia) differ from those that cause more-common types of pneumonia. The same is true of the germs that cause pneumonia in people with weak immune responses.
Community-acquired pneumonia
When you get pneumonia from contact with germs you encounter in the course of your normal routine, it's called community-acquired pneumonia. These commonplace germs generally cause mild forms of pneumonia that doctors can treat without difficulty. The microbes responsible for most community-acquired pneumonia are:
- Bacteria. The bacterium that causes most cases of community-acquired pneumonia is Streptococcus pneumoniae. Other possible agents include Staphylococcus aureus, Haemophilus influenzae and Klebsiella pneumoniae. It's not unusual to have pneumonia caused by more than one type of bacteria at a time. Methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant bacterium once found only in health care settings, now causes skin infections and pneumonia in the community, too.
- Bacteria-like organisms. Mycoplasma pneumoniae is a tiny organism that typically produces milder signs and symptoms than other types of pneumonia. Walking pneumonia, a term used to describe pneumonia that isn't severe enough to require bed rest, may result from Mycoplasma pneumoniae. Legionella and Chlamydia pneumonia are two other pneumonia-causing germs that are neither bacteria nor viruses.
- Viruses. Some of the same types of viruses that cause the flu and colds can also cause pneumonia. Although most cases of viral pneumonia are mild and resolve in time with rest and fluids, viral pneumonia caused by influenza viruses can become very serious. Viral pneumonia can set up a prime environment for the invasion of bacteria, causing a second infection.
- Fungi and parasites. Other less-common causes of community-acquired pneumonia include fungi, parasites and the germ that causes tuberculosis. Most cases of parasitic pneumonia occur in people who live or have traveled in developing countries.
Health-care-acquired pneumonia
Severe, difficult-to-treat bacterial pneumonia is a major problem in health care facilities — not only hospitals and nursing homes, but also kidney dialysis centers and outpatient infusion centers, where people regularly receive cancer chemotherapy and other intravenous medications.
Health-care-acquired pneumonia is sometimes caused by strains of Streptococcus pneumoniae and Haemophilus influenzae, which also occur in the community. But the list of germs causing hospital-acquired pneumonia doesn't stop there. In the hospital setting, bacteria may quickly become resistant to standard antibiotics, so drug resistant germs are much more common. Resistant bacteria such as Pseudomonas aeruginosa and MRSA make treatment difficult. People on breathing machines (ventilators), often used in hospital intensive care units, are particularly vulnerable.
With so many possible culprits and a high likelihood of resistant strains, the challenge in the hospital is to identify the causative organism and determine what antibiotics will work against it.
Inhalation or aspiration pneumonia
Aspiration pneumonia occurs when you breathe foreign matter into your lungs. This can happen if you vomit while asleep or unconscious and breathe in some of the contents of the stomach. Difficulty swallowing, which occurs with diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease and strokes, occasionally leads to aspiration pneumonia.
Opportunistic viral, bacterial and fungal pneumonias
These types of pneumonia strike people with weakened immune systems. Organisms that aren't harmful for healthy people can be dangerous for people who have had an organ transplant and people with AIDS and other conditions that impair the immune system. Medications that suppress your immune system, such as corticosteroids or chemotherapy, also can put you at risk of opportunistic pneumonia.
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